This book provides the most up-to-date review of the simian virus 40 (SV40) minichromosome as a model for the mammalian chromosome in studies of DNA replication. It focuses on disruption of DNA replication by anticancer drugs and DNA-damaging agents. There is a strong emphasis on the unique advantages of SV40 as an experimental system for the analysis of these classes of anticancer drug mechanisms. The new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication are covered in detail to aid readers in designing and interpreting similar experiments. Presents unique advantages of SV40 as an experimental system for the study of classes of anticancer drugs Details new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication Provides details to help the reader design and interpret similar experiments
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