Clinical Applications of Neurotrophic Factors

This volume provides a clinically relevant overview of the potential therapeutic applications of neurotrophic factors. Synthesizing data from basic science research, preclinical studies, and clinical trials, the authors explain what the different neurotrophic factors are and what these factors can realistically do to ameliorate various neurological disorders.The opening chapter describes the different neurotrophic factors and their biological functions. The second chapter discusses the key issues in the clinical use of these factors, such as choosing a neurotrophic factor, the goal of therapy, and the adverse effects of neurotrophic factor therapy. A major portion of the book focuses on specific clinical disorders for which particular neurotrophic factors are being investigated, including peripheral neuropathy, traumatic nerve injury, disorders of the visual and auditory systems, motor neuron disease, Parkinson's disease, Alzheimer's disease, and seizure disorders. The final chapter explores various methods for administering neurotrophic factors to the central nervous system.