Principles of Molecular Oncology

This complete updating and expansion of a highly praised survey of the molecular basis of cancer reflects emerging knowledge coming from genomics, proteomics, chemoprevention strategies, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small molecular weight compounds. New topics of special interest include the combining of molecular diagnostics (expression profiling of genes and proteins) with developmental therapeutics and the binary state concept (active/inactive) that seeks more relevant targets within the global molecular matrix of a given cancer. The book looks forward to new strategies that will not just attempt to kill cancer cells and cure cancers forever, but to hit those molecular targets to reduce the proliferative advantage of cancer cells and abolish or diminish their metastatic properties.