Genetic Instabilities and Neurological Diseases

This book describes everything about DNA repeat instability and neurological disorders, covering molecular mechanisms of repeat expansion, pathogenic mechanisms, clinical phenotype, parental gender effects, genotype-phenotype correlation, and diagnostic applications of the molecular data. The first edition of this book published in 1998 has become one of the most authoritative references for these disorders. This second edition provides excellent updates of these repeat expansion mutations. Many new chapters have been added, and old chapters have been newly written as extensions of the respective chapters of the previous edition. This book, representing most authorities of the field, is an invaluable reference source for diverse readers, including molecular biologists, neuroscientists, geneticists, neurologists, genetic counselors, and students. * Includes a CD-ROM with all of the figures * Contributions by most of the principal research teams in the area, edited by world-renowned leaders * Lays the background for future investigations on related diseases