Nuclear Matrix Structural and Functional Organization

Research on the nuclear matrix has grown enormously since Bereney and Coffey first reported its isolation and initial characterization in 1974. Since then, more than 1000 papers have been published on the subject by numerous workers around the world. This is the first book devoted to reviewing the major developments in this growing field. Key Features* The chapters cover a variety of topics, including:* Isolation of the nuclear matrix* Nuclear structure morphology in situ* Structural domains of the nuclear matrix and its components* Biochemistry and molecular biology of the matrix proteins and associated DNA and RNA* Functional properties associated with the nuclear matrix* DNA replication* Transcription* RNA splicing* Transcription regulation* Intranuclear and nucleocytoplasmic transport and targeting* Cell cycle regulation