Hematopoiesis Long-term Effects of Chemotherapy and Radiation

Cytotoxic injury to the bone marrow from drugs, chemicals, and radiation is an important problem. This reference critically assesses the implications of bone marrow damage by analyzing mechanisms of myelosuppression, possible mutagenic action, capacity to induce chromosome abnormalities, and effects on the immune system and other tissues. Hematopoiesis places clinical and experimental observations in the context of cell biology ... evaluates the effects of treatment, disease evolution, and the induced proliferative stress on the hemopoietic system ... concentrates on hemopoiesis within a clinical framework relating to immunology, cytogenetics, and leukemogenesis ... presents the subject in a logical sequence from fundamentals to future directions for research ... and looks at new research approaches to the therapy of malignancies. Including some 1,200 citations of pertinent literature plus many drawings, tables, and photographs, Hematopoiesis serves as an indispensable resource for hematologists, oncologists, cell and molecular biologists, immunologists, internists, radiation therapists, and bone marrow transplantation specialists. Book jacket.