The Basis of Toxicity Testing

This substantially updated edition presents fundamental principles and concepts behind the various types of toxicological studies, and explains how to design and conduct studies and interpret results. The text explains the increasing need to monitor, assess, and reevaluate the toxicity database of many agents and evaluates the place of individual studies in the overall toxicological assessment of a chemical. Concise descriptions of the formats of in vivo and in vitro studies and methods used in assessing endpoints of toxicity make this an essential introduction and guide for anyone who needs to understand or conduct toxicological studies.Reflecting increasing interest in the "Three Rs" (Reducing, Refining, and Replacement of existing animal tests) in recent years, the Second Edition includes much more information on a variety of new alternative testing protocols. Particular attention is given to the new in vitro alternative testing procedures being incorporated into EEC regulations. The text also covers studies required by regulatory agencies around the world.