DNA-protein Interactions Principles and Protocols

The clear and easy-to-follow protocols collected here illuminate the molecular basis of protein-nucleic acid interactions. They can be used to reveal the location of the DNA binding site, the strength and specificity of binding, the identities of individual groups on specific bases involved in binding, or the specific amino acid results of the protein that interact with the DNA. Some of the techniques can even be used to identify previously unknown DNA binding proteins from crude cell extracts.