Calcium Entry Channels in Non-excitable Cells

3.4.2 Activation Involves Extension of STIM1 Cytoplasmic Domain -- 3.4.3 CC1 and the Release of ORAI1-Interacting Machinery -- 3.4.4 Higher-Order STIM1 Oligomerization -- 3.5 Activation of ORAI1 Channels by STIM1 -- 3.5.1 Interaction of Activated STIM1 with ORAI1 -- 3.5.2 Gating of the ORAI1 Channel -- 3.6 Conclusions -- References -- Chapter 4: Modulation of Orai1 and STIM1 by Cellular Factors -- 4.1 Introduction -- 4.2 Modulators of Orai1 via Protein Interaction -- 4.3 Vesicular Components in Regulation of Orai1 -- 4.4 Store-Independent Regulation of Orai1 via Protein Interaction -- 4.5 STIM1-Interacting Molecules at the ER-PM Junctions -- 4.6 Modulators of STIM1 Function -- 4.7 STIM1 as a Regulator for Non-CRAC Channel-Related Functions -- 4.8 Methods Used to Identify Interacting Partners of Orai1 and STIM1 -- 4.9 Conclusions and Perspectives -- Acknowledgments -- References -- Chapter 5: CRAC Channels and Ca2+ -Dependent Gene Expression -- 5.1 Introduction -- 5.2 Ca2+ Entry through CRAC Channels Activates Gene Expression -- 5.3 The Importance of Ca2+ Microdomains near Open CRAC Channels in the Regulation of Transcription -- 5.4 How Local Is Local? -- 5.5 Sensing Local Ca2+ near CRAC Channels -- 5.6 Parallel Processing of the CRAC Channel Ca2+ Microdomain -- 5.7 Caveolin-1 Differentially Regulates NFAT and c-Fos Activities -- 5.8 Modular Regulation by Caveolin-1 -- 5.9 Large Bulk Ca2+ Rises and c-Fos Gene Expression -- 5.10 Conclusion -- References -- Chapter 6: Function of Orai/Stim Proteins Studied in Transgenic Animal Models -- 6.1 Introduction -- 6.2 Strategies for Gene Targeting -- 6.2.1 Conventional Gene Targeting -- 6.2.2 Conditional Gene Targeting -- 6.2.3 Gene Trapping -- 6.3 Establishment of Orai/Stim-Deficient Mice at the Whole-Body Level -- 6.3.1 Orai1 Knockout Mouse -- 6.3.2 Stim1 Knockout Mouse