Angiotension II Receptor Antagonists

The recent development of several new, non-peptide, orally active angiotensin IIreceptor antagonists is revolutionizing the treatment of patients with hypertension andvarious cardiovascular disorders. In this book experts review the current state ofangiotensin II antagonists and survey the progress of these diverse applications. Issuesrelating to angiotensin II and their receptors are examined in relation to their effects onthe kidney, non-diabetic renal disease, heart disease, diabetes mellitus, and variousother disorders. The combination of AT1 receptor antagonists with otherantihypertensive agents is reviewed in depth. The clinical attributes of these drugs arecomplemented by in-depth reviews of the physiology and pharmacology of angiotensinII peptides. The authors present the most recent findings in ligand recognition,activation, signal coupling, desensitization and functional alterations of vessels,especially small arteries, in patients with hypertension. This book constitutes the only available compendium on the clinical and experimental features of angiotensin II receptor antagonists. The unique features of the rapidly emerging class of drugs are surveyed throughout. Contributions have been made from international experts who have personally contributed to the discovery and development of these novel drugs. Recent cutting-edge physiology and pharmacology studies by renowned international experts provide a platform for considering the clinical applications of these agents.