Diagnosis and Treatment of Liver Fibrosis

Fibrosis is the clinical condition in which excess fibrous connective tissue forms in an organ or tissue in a reactive or reparative process. It can be a benign, reactive or pathological state. When fibrosis arises from a single cell line, the condition is known as fibroma. When it occurs as a response to injury, it is termed as scarring. When fibrosis occurs in the liver, the condition leads to cirrhosis. The fibrosis of the liver can lead to the destruction of normal tissues of the liver, including the sinusoids, vascular structures and the space of Disse. This results in increased hepatic blood flow resistance and portal hypertension. The pattern of fibrosis seen depends on the underlying insult that resulted in cirrhosis. Fibrosis can also proliferate if the underlying process causing it has been resolved. FibroTest is a biomarker test that can be used for the diagnosis of liver fibrosis. Close follow-up is necessary for its treatment. Antibiotics, laxatives, antiviral medications, steroid medications, etc. can help in the management of liver fibrosis and cirrhosis, even though the damage to the liver cannot be reversed. This book is compiled in such a manner, that it will provide in-depth knowledge about the treatment and diagnosis of liver fibrosis. It is a valuable compilation of topics ranging from the basic to the most complex advancements in the management of this medical condition. Students, researchers, experts and all associated with this area will benefit alike from this book.