Protein Engineering and Design

"Protein engineering refers to the process of developing useful or valuable proteins. In protein engineering, rational protein design and directed evolution strategies are used. The scientist uses detailed knowledge in rational protein design of the structure and function of the protein to make anticipated changes. Random mutagenesis is applied to a protein, and a selection regime is used to pick out variants that have the desired qualities Further rounds of mutation and selection are then applied. This book focuses on the topics elevant to the engineering, design and selection of proteins for use in biotechnology and therapy, and for understanding fundamental properties of activity, stability, folding, misfolding and disease."