Adhesion Molecules and Cell Signaling: Biology and Clinical Applications (Topics in Molecular Medicine, Vol 1)

This is the first volume of a new Raven Press series, Topics in Molecular Medicine. The series brings together leading basic and clinical scientists to explore the clinical applications of new insights into the molecular mechanisms of physiologic and pathophysiologic processes. Volume 1 focuses on the role of adhesion molecules in regulating physiologic and pathophysiologic cell-cell interactions in the circulation, the lymphatic system, and extravascular space. The first two sections examine the structure and regulation of the main classes of adhesion molecules: integrins, selectins, and intercellular adhesion molecules (ICAMs). Subsequent sections describe the role of these molecules in postangioplasty reactions, ischemia-reperfusion injury, atherogenesis, other vascular disorders, metastasis, and immunologic and inflammatory responses such as asthma and transplant rejection.