Advances in Biochemical Psychopharmacology

This volume examines the latest neurobiological and clinical research on depression and mania. Leading international experts highlight major advances ranging from molecular biology and genetics to behavioral studies, preclinical and clinical pharmacology, and prevention. The book begins with a review of the neurobiology of depression, with a particular focus on dopamine. Other topics covered include animal models of depression and mania; manipulation of inositol-linked second messenger systems as a therapeutic strategy in psychiatry; recent developments in genetics of bipolar illness; implications of a temperament-based classification of depression; pharmacological treatment of depression and comorbid anxiety disorders; and long-term prophylaxis of affective disorders.