Advances in Immunology

"The series which all immunologists need."--The Pharmaceutical Journal"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions."--Science"Deserves a permanent place in biomedical libraries as an aid in research and in teaching"--Journal of Immunological Methods"A provocative and scholarly review of research"--Journal of the American Medical Association"Provides an extremely valuable source of reference and many stimulating ideas...the main repository of information in a rapidly devloping subject"--The Lancet"Provides unrivalled value in both academic and fiscal terms and should be purchased by hard pressed librarians as a major priority to be jealously defended."--Journal of Medical Microbiology"A very valuable serial publication...no serious student of immunology can afford to be without it."--Archives of Biochemistry and BiophysicsKey Features* Focus on components of the V(D)J recombination machinery that might be related to diseases in humans and animals* Control of the complement system by control of C3/C5 convertase on host cells, control of fluid phase C3/C5 convertases, control of fluid phase MAC, and control of deposited MAC* Immunodeficiency resulting from a complete absence of MHC class II expression and two trans-acting factors controlling transcription* Current knowledge of IL-2R signaling, highlighting IL-2 signaling, and T-cell growth regulation* Functional role of CD40 in cells, the in vivo significance of CD40-CD40-L interactions, and the signal transduction machinery activated following crosslinking of the CD40 antigen* Integrative approach to better understand the observed heterogeneity of an individual response to allergens* Regulation of isotype specificity, switch recombination regulation, and the mechanism of switching* Two lymphocyte-specific proteins, RAG1 and RAG2, initiate V(D)J recombination of antigen receptor genes