Advances in Neurology

This volume presents the most recent and clinically relevant findings on neuronal regeneration, reorganization, and repair. Leading international investigators examine the diverse mechanisms by which the nervous system responds to injury and explore therapeutic interventions aimed at promoting functional recovery.The book provides extensive coverage of the neurobiology of spinal cord injury and describes strategies for enhancing functional recovery after spinal cord injury, including locomotor training, pharmacological interventions, and fetal tissue transplants. Close attention is given to evidence that injury-induced axonal sprouting, and the consequent formation of new synaptic connections, can contribute to epileptogenesis. Other topics discussed include mechanisms of action of growth factors and antioxidants in apoptosis; gene therapy and the use of stem cells for central nervous system regeneration; injury-stimulated neurogenesis in the inner ear and the retina; and long-term changes in motor neurons after injury.