Biodegradable Nano-Clusters As Drug Delivery Vehicles

The use of polymer nano particles (NPs) is of potential interest in the field of targeted drug delivery systems owing to multiple degrees of freedom like bio-degradability, hydrophobicity and the form (particles, capsules) in which they can be produced. The overall goal was to synthesize and characterize stable, monodisperse polymeric NPs loaded with drugs using flash nanoprecipitation in a Multi Inlet Vortex Mixer (MIVM)which could be used subsequently to build nano-clusters (NCs) comprising different drugs. The work further aimed at studying and optimizing drug encapsulation, loading and release kinetics from the synthesized NPs for different polymers.