Combination Drug Therapy for Hypertension

This volume reflects the growing recognition that combination therapy -- antihypertensive drugs with different modes of action -- is an effective way to reduce blood pressure, minimize dose-dependent side effects, and foster synergistic effects. Physicians will find the guidance they need to choose the best drug combinations for their patients.Coverage begins with a discussion of the limitations of monotherapy for hypertension and the rationale for combination therapy. Subsequent chapters examine specific combinations of antihypertensive drugs -- beta-blockers and diuretics; angiotensin-converting enzyme (ACE) inhibitors and diuretics; diuretics and angiotensin receptor inhibitors; calcium channel antagonists and diuretics; beta-blockers and calcium antagonists; beta-blockers and ACE inhibitors; calcium antagonists and ACE inhibitors; and combinations involving alpha-blockers. Other chapters discuss the ability of combination therapy to control stroke, renal disease, and risk factors for coronary atherosclerosis. Full consideration is also given to the long-term safety of various drug combinations, especially those involving calcium antagonists.