Developability of Biotherapeutics

Biopharmaceuticals are emerging as frontline medicines to combat several life-threatening and chronic diseases. They are currently the fastest growing group of pharmaceuticals, being a treatment option for a variety of chronic and sometimes life-threatening conditions. Biotherapeutics represent a diverse group of biological products that broadly encompasses nucleic acids, proteins, whole cells, viral particles, and vaccines. In recent years, great strides have been made towards the development of safer and more effective biotherapeutics, as well as in the adoption of cost-effective, more efficient, and streamlined manufacturing processes. This trend is expected to accelerate in the forthcoming years, as emerging fields related to advanced therapies or personalised medicine mature. Despite these progresses, there are still knowledge gaps across all stages of development, as well as technical and regulatory hurdles that can prevent the approval process of these products. In this title, a collection of topics covering relevant aspects in the field of biotherapeutics is presented. Developability of Biotherapeutics describes applications of computational and molecular modeling techniques that improve the overall process of discovery and development by removing empiricism. Collectively, this book provides a comprehensive view on the current advances taking place in the broad field of biotherapeutics and on the exciting challenges that lie ahead. This should be a valuable tool for professionals involved in industrial research and development, practitioners, scientists working with regulatory agencies, and pharmacy, medicine, and life science students and educators.