Estrogens and Antiestrogens: Basic and Clinical Aspects

This volume provides an up-to-date and comprehensive review of the basic and clinical aspects of tissue selective estrogens and antiestrogens. It covers all the major organ systems in which estrogen deficiency produces clinical entities that are likely to respond to tissue selective estrogens. The book is particularly timely because of the extensive clinical trials now in progress of new antiestrogens.The introductory section examines the chemistry, structure-function relationships, pharmacokinetics and pharmacodynamics, clinical pharmacology, and cellular actions of estrogens and antiestrogens and the clinical consequences of postmenopausal estrogen deficiency. Subsequent sections discuss the effects of estrogens and antiestrogens on the central nervous system, the cardiovascular system, bone and mineral metabolism, the breast, and the reproductive and urogenital tracts. Each of these sections contains a basic science chapter and a clinically oriented chapter. The concluding chapter explores the potential role of estrogens and antiestrogens in the treatment of postmenopausal women.