Frailty Pathophysiology, Phenotype and Patient Care

Cover -- Contents -- Preface -- Foreword -- Contributors -- Connecting Age-Related Biological Decline to Frailty and Late-Life Vulnerability -- Abstract -- Introduction -- Frailty Conceptualization -- Frailty Measurement -- The Biology That Underlies Frailty -- Disease States and Frailty -- Physiological System Dysregulation and Frailty -- Age-Related Cellular and Molecular Changes and Frailty -- Disclosure Statement -- References -- Cellular Senescence and the Biology of Aging, Disease, and Frailty -- Abstract -- Introduction -- Cellular Senescence, the Senescence-Associated Secretory Phenotype, and Aging -- Cellular Senescence and Age-Related Disease and Frailty -- Interventions Targeting Senescent Cells and the Senescence-Associated Secretory Phenotype -- Conclusions -- Acknowledgments -- Disclosure Statement -- References -- The Role of Genome Instability in Frailty: Mitochondria versus Nucleus -- Abstract -- Introduction -- Cellular and Mitochondrial Mechanisms of Nuclear Genome Instability -- Mitochondrial Quality Control and Nuclear Genome Stability -- Concluding Remarks -- Acknowledgments -- Disclosure Statement -- References -- Determinants of Frailty and Longevity: Are They the Same Ones? -- Abstract -- Introduction -- Longevity and Functional Reserve -- Disease, Functional Reserve, and Frailty -- Longevity and Frailty: Biological Background -- Disclosure Statement -- References -- Psychological Frailty in the Aging Patient -- Abstract -- Introduction -- Frailty -- Psychological Frailty -- Disclosure Statement -- References -- Frailty Clinical Phenotype: A Physical and Cognitive Point of View -- Abstract -- Introduction -- Physical Frailty: From Concept to Clinical Practice -- Cognitive Frailty: From Concept to Operational Definition -- Redefining Frailty: Emerging Definitions -- Conclusion -- Acknowledgments -- Disclosure Statement.