High-dose therapy with allogeneic or autologous stem cell transplantation, as well as additional supportive measures, have brought important advances in the therapy of malignant disease. Allogeneic and especially autologous peripheral stem cell grafting as opposed to allogeneic bone marrow transplantation is a subject of intense research. The book summarizes the most recent finding in this field, both in basic and clinical research, including newly developed methods. In this context, emphasis has been placed on:* acute and chronic myeloid and lymphocytic leukemia* multiple myeloma* myelodysplastic syndromes* aplastic anemia and autoimmune disease* certain solid tumors (carcinomas of the breast, the ovary, the bronchia, the germ cell, and soft tissue sarcoma)Novel approaches such as metakine transplantation and gene therapy are outlined from a theoretical as well as a practical point of view. The crucial question of early and late complications in allogeneic transplantation for solid tumors is dealt with in expert contributions. A special section is dedicated to cord blood transplantation. Finally, attention is drawn to further topics such as cell culture methods or the identification and separation of growth factors in hematopoietic stem cell cultures. With its international team of authors, the book presents the state of the art in the field of high-dose therapy of malignant and non-malignant diseases.
Be the first to review this book!
