Medical Defense Against Mustard Gas Toxic Mechanisms and Pharmacological Implications

This book provides a comprehensive review and analysis of the acute toxic effects of sulfur mustard (mustard gas); the injuries that this compound produces in skin, eye, airway, and other tissues; and possibilities for the prevention of these injuries through pharmacological intervention. The book takes a multidisciplinary approach and is intended for all biomedical researchers interested in combatting the effects of chemical weapons, as well as those who have a general interest in the basic processes underlying cell death and tissue injury. Drawing on an extensive base of scientific literature, including many government research reports that are difficult or impossible for most researchers to obtain, the book covers the pathological features of acute mustard injury, sulfur mustard's toxicodynamics, its chemistry, its molecular and cellular mechanisms of injury, the inflammatory mechanisms involved in injury, prophylactic and therapeutic approaches to prevention of injury, and experimental models of mustard injury.