Novel Therapies for CNS Injuries Rationales and Results

This book provides reviews of the epidemiology, evaluation, and patient management of central nervous system (CNS) injuries. Internationally recognized clinicians and basic scientists discuss recent research that has significantly advanced the understanding of the pathophysiology of neuronal death and facilitated development of new therapeutic approaches.Novel therapeutic agents evaluated in animal models and currently in clinical trials include:calcium antagonistsglutamate receptor antagonistsinhibitors of glutamate releaseendothelial adhesion and nerve growth factorsopioidsantioxidants, gangliosidesthrombolytic agentsAll of these options, as well as hypothermia as a potentially therapeutic approach, are discussed in this comprehensive volume. It will be invaluable to neurologists, neurosurgeons, intensivists, and emergency medicine physicians who care for CNS injured patients.