Quantitative Analysis of Drugs in Pharmaceutical Formulations

Selection of a suitable analyticat method for estimation of individual drug in any multi-compound dosage form will always remain a challenge for an analytical chemist. The method so selected should provide analytical data as accurate as required, technically sound. Defensible with low limit of uncertainty and above all amenable to routine laboratory use and capable of being performed by personnel with minimum technical experience. Analytical methods for about 290 multi- component formulations in 18 chapters have been described with reasonable details to be reproduced without much difficulty, however, some degree of optimization and analytical skill may be required in certain cases. The methods for about 100 new formulations have been included while exhaustively revising- and up-dating the text. Methods which are obsolete have been deleted. Three additional chapters, i.e., Cardiac Drugs, Sedatives & Tranquillisers, and General Guidelines for Accreditation of Calibrating & Testing Laboratories with NABL, have been incorporated, the latter being extremely informative and useful for institutions seeking accreditation. Quality level of any analytical work primarily depends on the expertise of the analyst, based on the level of skill and practical experience attained; the analysts have been broadly grouped into five grades, enabling the quality control manager to assign analytical functions accordingly. Essential qualities of an analyst elaborated in the text should enable the analyst to evaluate his own performance periodically to maintain highest standards of analytical work.