Although the problem of drug resistance in clinical settings is complex, much progress has been achieved in basic research by molecular, biological, and biochemical approaches, clarifying the mechanisms of pleiotropic drug resistance. Those findings can now be used in clinical cancer chemotherapy to overcome the resistance of cancer cells, although problems remain regarding the continued resistance of even a few cells. This symposium focused on the mechanism of drug resistance in cancer cells and the circumvention of this resistance. The volume is divided into four parts: P-glycoprotein and MDR gene; enzyme features related with drug resistance; signal transduction related with drug resistance; and overcoming of drug resistance. Annotation copyright Book News, Inc. Portland, Or.
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