The New Macrolides Azalides and Streptogramins: Pharmacology and Clinical Applications

This timely reference addresses the important aspects of the chemistry of the macrolides, azalides, and streptogramins; illustrates how the compounds are related; and details what structural changes are essential to achieve improved antibacterial activity and pharmacology.;Explains the in vitro activity of the new agents and compounds them to other compounds used to treat outpatient infections. Presenting the proceeding of the first international conference on the topic, The New Macrolides, Azalides, and Streptogramins discusses the intracellular activity of azalides and new macrolides against Chlamydia, Staphyloccus aureus, Listeria monocytogenes, Legionella species, etc., demonstrates the potential uses of clarithromycin, roxithromycin, and azithromycin through animal models, reviews the safety of the newly developed macrolides and macrolide-like antibiotics and summarizes drug interactions.;Describes the use of macrolides for treating respiratory infections, skin and skin structure infections, sexually transmitted diseases, and gastriontestinal infections, contains clinical trial findings of eight macrolides used to treat significant infections in children, considers the use of macrolides to manage difficult-to-treat conditions associated with HIV infection, revels the dramatic results of using clarithromycin in combination with minocycline to clear lepromatous lesions....and much more!;The New Macrolides, Azalides, and Streptogramins serves as an excellent source for infectious disease specialists and pulmonologists, internists, pharmacologists and pharmacists, microbiologists, pediatricians, epidemiologists, and medicinal and biological chemists.