Varicella-Zoster Virus Virology and Clinical Management

The successful development of a VZV vaccine reflects intense research interest in this virus over recent years. This comprehensive account of the biology and clinical features of the varicella-zoster virus, published in association with the VZV Research Foundation, surveys current knowledge of the molecular biology, pathogenesis, and clinical features of VZV as the causative agent of chickenpox and zoster (shingles). The volume covers such topics as viral replication, latency, immune mechanisms, epidemiology and disease manifestations, and complications of varicella and zoster. Also included is detailed information on live attenuated varicella vaccine, treatment strategies, and the management of postherpetic pain in zoster patients. As the most authoritative review and guide to the virus and its diseases, this book will appeal to a wide range of clinicians and investigators, including pediatricians, geriatricians, neurologists, dermatologists, infectious disease specialists, and virologists interested in the herpes viruses.