Peptide Drug Delivery to the Brain (Order Code 2266)

This volume is the first comprehensive discussion of established and new strategies for delivering peptides and antibodies through the blood-brain barrier--the chief obstacle that must be overcome before these promising new drugs can be used successfully in treatment of brain diseases. The author reviews current concepts on blood-brain barrier transport biology, assesses the utility and limitations of traditional brain drug delivery methods, and describes new drug delivery techniques that have emanated from recent research on the cell and molecular biology of brain capillaries. Close attention is given to strategies for developing blood-brain barrier transport vectors and synthesizing chimeric peptides that can cross the blood-brain barrier. The book includes 147 illustrations and nearly 900 references to the current literature.